The objective of this contract is to conduct a third series of studies over a nine year period designed to 1) conduct the first longitudinal study of age effects on cardiavescular function in the BLSA population by repeating gated blood pool scan examinations during rest and exercise; 2) determine the effect of ischemic heart disease on cardiac function in the BLSA participants and how age alters that effect; 3) assess the effect of physical conditioning status and body composition on the central and peripheral cardiovascular response to exercise in the BLSA population; 4) perform exercise tomographic thallium scintigraphy so as to insurue the absence of subclinical disease in the BLSA participants chosen for the above studies of cardiovascular function; and 5) conduct a longitudinal assessment of age related incidence and prognostic significance of a change in myocadial flow distribution over an 8-10 year period.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research and Development Contracts (N01)
Project #
N01AG092116-005
Application #
2294305
Study Section
Project Start
1989-09-30
Project End
1998-09-29
Budget Start
1994-06-29
Budget End
1995-09-29
Support Year
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Fleg, J L; O'Connor, F; Gerstenblith, G et al. (1995) Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J Appl Physiol 78:890-900