This contract is one part of the pre-clinical portion of the NIAID Antiviral Substances Program. The Program supports six separate awards to investigators who have developed animal models of viral infections which can be used to test the activity of antiviral agents in vivo. Compounds are evaluated for efficacy both therapeutically and prophylactically. Studies of drug toxicity and effects of drug treatment on the immune response to infection are also pursued. Combination chemotherapy studies are encouraged. The currently awarded series of contractors have at their disposal the following models: University of Alabama - herpes encephalitis in the mouse, neonatal herpes in the mouse, genital herpes in the guinea pig, murine cytomegalovirus in the mouse; Utah State University - influenza in the mouse; Baylor College of Medicine - respiratory syncytial, parainfluenza and measles viruses in the cotton rat; Massachusetts Eye Research Institute, varicella-zoster virus and human cytomegalovirus in the rabbit; Cincinnati Children's Hospital - genital herpes, neonatal herpes and cytomegalovirus in the guinea pig; and, University of Texas at Galveston - coxsackievirus in the mouse.
| Wyde, P R; Moore, D K; Pimentel, D M et al. (1996) Recombinant superoxide dismutase (SOD) administered by aerosol inhibits respiratory syncytial virus infection in cotton rats. Antiviral Res 31:173-84 |
| Wyde, P R; Ambrose, M W; Meyerson, L R et al. (1993) The antiviral activity of SP-303, a natural polyphenolic polymer, against respiratory syncytial and parainfluenza type 3 viruses in cotton rats. Antiviral Res 20:145-54 |
| Attibele, N; Wyde, P R; Trial, J et al. (1993) Measles virus-induced changes in leukocyte function antigen 1 expression and leukocyte aggregation: possible role in measles virus pathogenesis. J Virol 67:1075-9 |
| Wyde, P R; Ambrose, M W; Voss, T G et al. (1992) Measles virus replication in lungs of hispid cotton rats after intranasal inoculation. Proc Soc Exp Biol Med 201:80-7 |
