This contract is the major component of the Antiviral Research Branch's Clinical Trials program. The objectives are to evaluate experimental therapies for severe herpesvirus infections. Studies to be undertaken in the coming project period include: the evaluation of BVaraU for the treatment of shingles in patients who are immunosuppressed due to cancer chemotherapy or HIV infection, the evaluation of ganciclovir or a monoclonal antibody for the therapy of symptomatic congenital cytomegalovirus infection, suppressive acyclovir therapy for infants with localized neonatal herpes and herpes encephalitis. In addition, data on the natural history, immune response to and epidemiology of these diseases will be collected. A pilot study to determine the factors which influence the frequency of transmission of herpes simplex virus to the neonate at birth with continued.
| Abzug, Mark J; Michaels, Marian G; Wald, Ellen et al. (2016) A Randomized, Double-Blind, Placebo-Controlled Trial of Pleconaril for the Treatment of Neonates With Enterovirus Sepsis. J Pediatric Infect Dis Soc 5:53-62 |
| Pinninti, Swetha G; Kimberlin, David W (2014) Management of neonatal herpes simplex virus infection and exposure. Arch Dis Child Fetal Neonatal Ed 99:F240-4 |
| Kamal, M A; Acosta, E P; Kimberlin, D W et al. (2014) The posology of oseltamivir in infants with influenza infection using a population pharmacokinetic approach. Clin Pharmacol Ther 96:380-9 |
| Kimberlin, David W; Acosta, Edward P; Prichard, Mark N et al. (2013) Oseltamivir pharmacokinetics, dosing, and resistance among children aged <2 years with influenza. J Infect Dis 207:709-20 |
| Pinninti, Swetha G; Kimberlin, David W (2013) Maternal and neonatal herpes simplex virus infections. Am J Perinatol 30:113-9 |
| Pinninti, Swetha G; Kimberlin, David W (2013) Neonatal herpes simplex virus infections. Pediatr Clin North Am 60:351-65 |
| Kimberlin, David W; Baley, Jill; Committee on infectious diseases et al. (2013) Guidance on management of asymptomatic neonates born to women with active genital herpes lesions. Pediatrics 131:e635-46 |
| Kimberlin, David W; Whitley, Richard J; Wan, Wen et al. (2011) Oral acyclovir suppression and neurodevelopment after neonatal herpes. N Engl J Med 365:1284-92 |
| Acosta, Edward P; Jester, Penelope; Gal, Peter et al. (2010) Oseltamivir dosing for influenza infection in premature neonates. J Infect Dis 202:563-6 |
| Kimberlin, David W; Shalabi, Marwan; Abzug, Mark J et al. (2010) Safety of oseltamivir compared with the adamantanes in children less than 12 months of age. Pediatr Infect Dis J 29:195-8 |
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