Establish a cohort of 1,000 homosexually active men to be followed for two and a half years for development of Acquired Immune Deficiency Syndrome (AIDS), persistent lymphadenopathy, and changes in T-cell subsets. Participants will be recruited through gay organizations, networking, etc. Final selection criteria are sexual relations with an AIDS case, large number of partners, persistent lymphadenopathy, or T-cell subset abnormalities. The baseline screening will include sexual and medical history, physical examination, and collection of blood, feces, urine, and semen. Follow-up examinations will be done every six months. Specimen aliquots will be stored for future use.
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| Solomon, R E; Kaslow, R A; Phair, J P et al. (1988) Human immunodeficiency virus and hepatitis delta virus in homosexual men. A study of four cohorts. Ann Intern Med 108:51-4 |
| Saah, A J; Farzadegan, H; Fox, R et al. (1987) Detection of early antibodies in human immunodeficiency virus infection by enzyme-linked immunosorbent assay, Western blot, and radioimmunoprecipitation. J Clin Microbiol 25:1605-10 |
| Detels, R; Visscher, B R; Fahey, J L et al. (1987) Predictors of clinical AIDS in young homosexual men in a high-risk area. Int J Epidemiol 16:271-6 |
