Abstract

We will prospectively study health-related and life-style characteristics of male homosexuals in a low incidence area for AIDS, i.e., Pittsburgh-Tri-state area. The goal is to uncover antecedents and risk factors of AIDS. We will study a cohort of 7,000-10,000 gay males for two and one half years each for development of AIDS and for the effect of introduction of the putative AIDS agent. This includes collection of sera for the AIDS Repository, medical-sexual-travel data, and screening for AIDS by questionnaire.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI032513-023
Application #
2295645
Study Section
Project Start
1983-09-30
Project End
Budget Start
1987-09-11
Budget End
1987-09-29
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Microbiology/Immun/Virology
Type
Schools of Public Health
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Silvestre, A J (1994) Brokering: a process for establishing long-term and stable links with gay male communities for research and public health education. AIDS Educ Prev 6:65-73
Silvestre, A J; Kingsley, L A; Wehman, P et al. (1993) Changes in HIV rates and sexual behavior among homosexual men, 1984 to 1988/92. Am J Public Health 83:578-80
Rinaldo Jr, C R; Kingsley, L A; Ho, M et al. (1992) Enhanced shedding of cytomegalovirus in semen of human immunodeficiency virus-seropositive homosexual men. J Clin Microbiol 30:1148-55
Rahman, M A; Kingsley, L A; Atchison, R W et al. (1991) Reactivation of Epstein-Barr virus during early infection with human immunodeficiency virus. J Clin Microbiol 29:1215-20
Rinaldo Jr, C R (1990) Immune suppression by herpesviruses. Annu Rev Med 41:331-8
Kingsley, L A; Armstrong, J; Rahman, A et al. (1990) No association between herpes simplex virus type-2 seropositivity or anogenital lesions and HIV seroconversion among homosexual men. J Acquir Immune Defic Syndr 3:773-9
Cai, Q; Huang, X L; Rappocciolo, G et al. (1990) Natural killer cell responses in homosexual men with early HIV infection. J Acquir Immune Defic Syndr 3:669-76
Kingsley, L A; Rinaldo Jr, C R; Lyter, D W et al. (1990) Sexual transmission efficiency of hepatitis B virus and human immunodeficiency virus among homosexual men. JAMA 264:230-4
Rinaldo, C; Kingsley, L; Neumann, J et al. (1989) Association of human immunodeficiency virus (HIV) p24 antigenemia with decrease in CD4+ lymphocytes and onset of acquired immunodeficiency syndrome during the early phase of HIV infection. J Clin Microbiol 27:880-4
Rappocciolo, G; Toso, J F; Torpey 3rd, D J et al. (1989) Association of alpha interferon production with natural killer cell lysis of U937 cells infected with human immunodeficiency virus. J Clin Microbiol 27:41-8

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