Discover new antifungal agents with potential utility specifically for the treatment of disseminated Candidiasis, a common opportunistic infection in immunocompromised individuals. This goal will be accomplished by the initial in vitroevaluation of anti-Candidal activity of extracts of higher plants and microorganisms. Pure antifungal compounds will beisolated with the aid of a bioassay-directed fractionation and purification scheme. The pure antifungal agents will be evaluated in vivo for efficacy, toxicity, synergism, and their effect on the immune system using a mouse model of disseminated Candidiasis.

Project Start
1984-07-23
Project End
1987-07-22
Budget Start
1986-02-10
Budget End
1987-07-22
Support Year
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Mississippi
Department
Type
Schools of Pharmacy
DUNS #
City
University
State
MS
Country
United States
Zip Code
38677
Jurgens, T M; Hufford, C D; Clark, A M (1992) The metabolism of muzigadial by microorganisms. Xenobiotica 22:569-77
Liu, S C; Oguntimein, B; Hufford, C D et al. (1990) 3-Methoxysampangine, a novel antifungal copyrine alkaloid from Cleistopholis patens. Antimicrob Agents Chemother 34:529-33
Hufford, C D; Liu, S C; Clark, A M (1988) Antifungal activity of Trillium grandiflorum constituents. J Nat Prod 51:94-8
Hufford, C D; Liu, S; Clark, A M et al. (1987) Anticandidal activity of eupolauridine and onychine, alkaloids from Cleistopholis patens. J Nat Prod 50:961-4
Clark, A M; Watson, E S; Ashfaq, M K et al. (1987) In vivo efficacy of antifungal oxoaporphine alkaloids in experimental disseminated candidiasis. Pharm Res 4:495-8
Adeoye, A O; Oguntimein, B O; Clark, A M et al. (1986) 3-Dimethylallylindole: an antibacterial and antifungal metabolite from Monodora tenuifolia. J Nat Prod 49:534-7