Abstract

The major objective of this proposal is to provide a resource for the continuing evaluation of antiviral chemotherapeutic agents in experimental animal infections which are models of human herpesvirus diseases. The investigations of a new antiviral compound provided by the Antiviral Substances Program of NIAID include: 1) a determination of the in vitro activity of the drug against appropriate representative viruses in both mouse and human tissue culture cells, and 2) an evaluation of the efficacy of the compound in the treatment of appropriate experimental viral infections in animal models of herpes simplex virus and cytomegalovirus infections.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI065290-004
Application #
6070627
Study Section
Project Start
1995-11-30
Project End
2000-11-30
Budget Start
1999-02-08
Budget End
1999-11-30
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Pediatrics
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Parker, Jacqueline N; Pfister, Luz-Andrea; Quenelle, Debra et al. (2006) Genetically engineered herpes simplex viruses that express IL-12 or GM-CSF as vaccine candidates. Vaccine 24:1644-52
Kern, Earl R; Hartline, Caroll B; Rybak, Rachel J et al. (2004) Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections. Antimicrob Agents Chemother 48:1749-55
Bidanset, Deborah J; Rybak, Rachel J; Hartline, Caroll B et al. (2004) Efficacy of ganciclovir and cidofovir against human cytomegalovirus replication in SCID mice implanted with human retinal tissue. Antiviral Res 63:61-4
Kern, E R; Rybak, R J; Hartline, C B et al. (2001) Predictive efficacy of SCID-hu mouse models for treatment of human cytomegalovirus infections. Antivir Chem Chemother 12 Suppl 1:149-56
Bidanset, D J; Placidi, L; Rybak, R et al. (2001) Intravenous infusion of cereport increases uptake and efficacy of acyclovir in herpes simplex virus-infected rat brains. Antimicrob Agents Chemother 45:2316-23
Hostetler, K Y; Rybak, R J; Beadle, J R et al. (2001) In vitro and in vivo activity of 1-O-hexadecylpropanediol-3-phospho-ganciclovir and 1-O-hexadecylpropanediol-3-phospho-penciclovir in cytomegalovirus and herpes simplex virus infections. Antivir Chem Chemother 12:61-70
Kern, E R; Palmer, J; Szczech, G et al. (2000) Efficacy of topical acyclovir monophosphate, acyclovir, or penciclovir in orofacial HSV-1 infections of mice and genital HSV-2 infections of guinea pigs. Nucleosides Nucleotides Nucleic Acids 19:501-13
Fleck, M; Mountz, J D; Hsu, H C et al. (1999) Herpes simplex virus type 2 infection induced apoptosis in peritoneal macrophages independent of Fas and tumor necrosis factor-receptor signaling. Viral Immunol 12:263-75
Fleck, M; Kern, E R; Zhou, T et al. (1998) Murine cytomegalovirus induces a Sjogren's syndrome-like disease in C57Bl/6-lpr/lpr mice. Arthritis Rheum 41:2175-84