The overall objective of this project, """"""""Clinical Studies of Therapies for Virus Infections"""""""", is to conduct clinical trial/studies to evaluate promising therapies for the treatment of acute and chronic human viral diseases that are deemed medically and scientifically important by the National Institute of Allergy and Infectious Diseases. This program will facilitate advances in clinical antiviral therapy by rigorously evaluating the efficacy and safety of new therapeutic regimens for serious viral diseases in adult and pediatric immunocompromised and immune competent patient populations. In addition, data on disease natural history, pathogenesis and epidemiology will be conducted and evaluated in order to enhance our understanding of viral disease processes and to help in deciding new strategies for future trials.
| Abzug, Mark J; Michaels, Marian G; Wald, Ellen et al. (2016) A Randomized, Double-Blind, Placebo-Controlled Trial of Pleconaril for the Treatment of Neonates With Enterovirus Sepsis. J Pediatric Infect Dis Soc 5:53-62 |
| Pinninti, Swetha G; Kimberlin, David W (2014) Management of neonatal herpes simplex virus infection and exposure. Arch Dis Child Fetal Neonatal Ed 99:F240-4 |
| Kamal, M A; Acosta, E P; Kimberlin, D W et al. (2014) The posology of oseltamivir in infants with influenza infection using a population pharmacokinetic approach. Clin Pharmacol Ther 96:380-9 |
| Kimberlin, David W; Acosta, Edward P; Prichard, Mark N et al. (2013) Oseltamivir pharmacokinetics, dosing, and resistance among children aged <2 years with influenza. J Infect Dis 207:709-20 |
| Pinninti, Swetha G; Kimberlin, David W (2013) Maternal and neonatal herpes simplex virus infections. Am J Perinatol 30:113-9 |
| Pinninti, Swetha G; Kimberlin, David W (2013) Neonatal herpes simplex virus infections. Pediatr Clin North Am 60:351-65 |
| Kimberlin, David W; Baley, Jill; Committee on infectious diseases et al. (2013) Guidance on management of asymptomatic neonates born to women with active genital herpes lesions. Pediatrics 131:e635-46 |
| Kimberlin, David W; Whitley, Richard J; Wan, Wen et al. (2011) Oral acyclovir suppression and neurodevelopment after neonatal herpes. N Engl J Med 365:1284-92 |
| Acosta, Edward P; Jester, Penelope; Gal, Peter et al. (2010) Oseltamivir dosing for influenza infection in premature neonates. J Infect Dis 202:563-6 |
| Kimberlin, David W; Shalabi, Marwan; Abzug, Mark J et al. (2010) Safety of oseltamivir compared with the adamantanes in children less than 12 months of age. Pediatr Infect Dis J 29:195-8 |
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