The primary activity of the contract will be to evaluate (i) therapeutic approaches and (ii) inhibitors of mucosal transmission alone and in combination. The term """"""""therapeutic approaches"""""""" includes, but is not limited to, the following: antiviral agents (drugs and biologics), immune-based strategies, and gene-based therapy. The term """"""""transmission inhibitor"""""""" includes drug-based, immune-based, biologics, and natural product inhibitors of sexual transmission. Excluded from these studies is prophylactic vaccine-based suppression of viral transmission. Evaluation encompasses the determination of efficacy and toxicity and when needed, limited pharmacokinetics. Model development will continue to be an integral part of this program only with respect to improving existing models.

Project Start
1996-08-30
Project End
2001-08-25
Budget Start
1999-05-24
Budget End
2000-08-25
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Tulane University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Nomura, Laurel E; deHaro, Eileen D; Martin, Louis N et al. (2003) Optimal preparation of rhesus macaque blood for cytokine flow cytometric analysis. Cytometry A 53:28-38
Wilson, L A; Murphey-Corb, M; Martin, L N et al. (2000) Identification of SIV env-specific CTL in the jejunal mucosa in vaginally exposed, seronegative rhesus macaques (Macaca mulatta). J Med Primatol 29:173-81