Pneumocysitis Carinii Infection Therapies - Preclin Eval

Walzer, Peter D.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research and Development Contracts (N01)
• Project #: N01AI075319-000
• Application #: 2651634
• Project Start: 1997-09-01
• Project End: 2002-08-30
• Budget Start: 1997-09-01
• Budget End: 1998-09-30
• Fiscal Year: 1997

Institution

• Name: University of Cincinnati
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• City: Cincinnati
• State: OH
• Country: United States
• Zip Code: 45221

Publications

Cushion, Melanie T; Linke, Michael J; Ashbaugh, Alan et al. (2010) Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection. PLoS One 5:e8524

Joffrion, Tiffany M; Collins, Margaret S; Sesterhenn, Thomas et al. (2010) Functional characterization and localization of Pneumocystis carinii lanosterol synthase. Eukaryot Cell 9:107-15

Vale, Nuno; Collins, Margaret S; Gut, Jiri et al. (2008) Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. Bioorg Med Chem Lett 18:485-8

Sesterhenn, Thomas M; Cushion, Melanie T; Slaven, Bradley E et al. (2006) Sequence of the mitochondrial genome of Pneumocystis carinii: implications for biological function and identification of potential drug targets. J Eukaryot Microbiol 53 Suppl 1:S154-5

Joffrion, Tiffany M; Collins, Margaret S; Cushion, Melanie T (2006) Microaerophilic conditions increase viability and affect responses of Pneumocystis carinii to drugs in vitro. J Eukaryot Microbiol 53 Suppl 1:S117-8

Cushion, Melanie T; Walzer, Peter D; Collins, Margaret S et al. (2004) Highly active anti-Pneumocystis carinii compounds in a library of novel piperazine-linked bisbenzamidines and related compounds. Antimicrob Agents Chemother 48:4209-16

Vanden Eynde, Jean Jacques; Mayence, Annie; Huang, Tien L et al. (2004) Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia. Bioorg Med Chem Lett 14:4545-8

Collins, M S; Cushion, M T (2001) Standardization of an in vitro drug screening assay by use of cryopreserved and characterized Pneumocystis carinii populations. J Eukaryot Microbiol Suppl:178S-179S

Cushion, M T; Collins, M; Hazra, B et al. (2000) Effects of atovaquone and diospyrin-based drugs on the cellular ATP of Pneumocystis carinii f. sp. carinii. Antimicrob Agents Chemother 44:713-9

Cushion, M T; Linke, M J; Collins, M et al. (1999) The minimum number of Pneumocystis carinii f. sp. carinii organisms required to establish infections is very low. J Eukaryot Microbiol 46:111S