The objectives of this contract are to gain knowledge about infection of the nervous system with Borrelia burgdorferi in the Rhesus macaque animal model that would aid in the diagnosis and treatment of human Lyme neuroborreliosis (LNB). This includes: (a) optimizing the current experimental model of LNB in non-human primates; (b) learning more about neurotropism and neuropathogenicity in the expression of LNB, as well as the mechanisms involved; and (c) determining whether long-term infection with B. burgdorferi results in damage to the central and/or peripheral nervous system.
| Li, Libin; Narayan, Kavitha; Pak, Elena et al. (2006) Intrathecal antibody production in a mouse model of Lyme neuroborreliosis. J Neuroimmunol 173:56-68 |
| Narayan, Kavitha; Dail, Donna; Li, Libin et al. (2005) The nervous system as ectopic germinal center: CXCL13 and IgG in lyme neuroborreliosis. Ann Neurol 57:813-23 |
| Pachner, Andrew R; Dail, Donna; Bai, Yunhong et al. (2004) Genotype determines phenotype in experimental Lyme borreliosis. Ann Neurol 56:361-70 |
| Pachner, A R; Dail, D; Li, L et al. (2002) Humoral immune response associated with lyme borreliosis in nonhuman primates: analysis by immunoblotting and enzyme-linked immunosorbent assay with sonicates or recombinant proteins. Clin Diagn Lab Immunol 9:1348-55 |
| Pachner, A R; Cadavid, D; Shu, G et al. (2001) Central and peripheral nervous system infection, immunity, and inflammation in the NHP model of Lyme borreliosis. Ann Neurol 50:330-8 |
