The Tuberculosis Research Unit contract is part of NIAID's response to the global resurgence of tuberculosis (TB). The major elements of its Statement of Work include: 1) Develop and implement a systematic approach towards furthering scientific understanding of the epidemiology of TB in populations with a high prevalence of disease; 2) Conduct coordinated, multi-disciplinary investigations of human host immunologic response mechanisms to M. tuberculosis in order to identify and validate surrogate markers for clinical use; 3) Conduct an investigation of the microbial factors expressed during various stages of M. tuberculosis infection and illness to identify surrogate markers for ultimate use in clinical trials of novel therapeutic and prevention strategies for TB; 4) Conduct human studies of potential interventions such as new vaccines, prophylactic or therapeutic regimens, using developed candidate surrogate markers of M. tuberculosis infection, TB progression and/or host protection to evaluate the validity of using these markers in future clinical trials and the safety and efficacy of new regimens; and 5) Establish and/or maintain a repository of clinical samples, including but not limited to sera and sputa from patients involved in clinical trials supported by the TBRU, and human tissue samples from well-characterized TB patients and controls, where feasible and appropriate, and distribute these specimens to qualified investigators, with approval of the Project Officer. The TBRU maintains clinical research sites in the United States, Brazil and Uganda.

Project Start
1999-12-01
Project End
2006-11-30
Budget Start
1999-12-01
Budget End
2001-07-15
Support Year
Fiscal Year
2000
Total Cost
$4,100,000
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Stein, Catherine M; Zalwango, Sarah; Malone, LaShaunda L et al. (2018) Resistance and Susceptibility to Mycobacterium tuberculosis Infection and Disease in Tuberculosis Households in Kampala, Uganda. Am J Epidemiol 187:1477-1489
Colangeli, Roberto; Jedrey, Hannah; Kim, Soyeon et al. (2018) Bacterial Factors That Predict Relapse after Tuberculosis Therapy. N Engl J Med 379:823-833
Martinez, Leonardo; Handel, Andreas; Shen, Ye et al. (2018) A Prospective Validation of a Clinical Algorithm to Detect Tuberculosis in Child Contacts. Am J Respir Crit Care Med 197:1214-1216
Suliman, Sara; Thompson, Ethan; Sutherland, Jayne et al. (2018) Four-gene Pan-African Blood Signature Predicts Progression to Tuberculosis. Am J Respir Crit Care Med :
Martinez, Leonardo; Shen, Ye; Handel, Andreas et al. (2018) Effectiveness of WHO's pragmatic screening algorithm for child contacts of tuberculosis cases in resource-constrained settings: a prospective cohort study in Uganda. Lancet Respir Med 6:276-286
Bark, Charles M; Manceur, Ameur M; Malone, LaShaunda L et al. (2017) Identification of Host Proteins Predictive of Early Stage Mycobacterium tuberculosis Infection. EBioMedicine 21:150-157
Lewinsohn, Deborah A; Swarbrick, Gwendolyn M; Park, Byung et al. (2017) Comprehensive definition of human immunodominant CD8 antigens in tuberculosis. NPJ Vaccines 2:
Hirsch, Christina S; Rojas, Roxana; Wu, Mianda et al. (2016) Mycobacterium tuberculosis Induces Expansion of Foxp3 Positive CD4 T-cells with a Regulatory Profile in Tuberculin Non-sensitized Healthy Subjects: Implications for Effective Immunization against TB. J Clin Cell Immunol 7:
Martinez, Leonardo; Sekandi, Juliet N; Castellanos, María E et al. (2016) Infectiousness of HIV-Seropositive Patients with Tuberculosis in a High-Burden African Setting. Am J Respir Crit Care Med 194:1152-1163
Suliman, Sara; Geldenhuys, Hennie; Johnson, John L et al. (2016) Bacillus Calmette-Guérin (BCG) Revaccination of Adults with Latent Mycobacterium tuberculosis Infection Induces Long-Lived BCG-Reactive NK Cell Responses. J Immunol 197:1100-1110

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