Abstract

The objective of the acquisition is to support preclinical evaluation of biomedical products such as topical microbicides, vaccines, or therapeutics aimed at prevention and control of sexually transmitted diseases (STDs) in the non-human primate model. Diseases or pathogens of interest include, but are not limited to: chlamydial infection; gonorrhea; syphilis; chancroid; human papillomavirus (HPV) infection; genital herpes (herpes simplex virus 1 and 2 infections), human herpes virus 8 (Kaposi's sarcoma virus) and human or simian immunodeficiency virus (HIV or SIV) infection as a co-infection with other STDs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI095388-002
Application #
6409825
Study Section
Project Start
1999-09-24
Project End
Budget Start
2000-09-28
Budget End
2001-12-31
Support Year
Fiscal Year
2000
Total Cost
$1,017,726
Indirect Cost

  Institution

Name
University of Washington
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Patton, Dorothy L; Teng, Andy; Randall, Arlo et al. (2014) Whole genome identification of C. trachomatis immunodominant antigens after genital tract infections and effect of antibiotic treatment of pigtailed macaques. J Proteomics 108:99-109
Patton, Dorothy L (2012) A guide for standardizing colposcopic observations for the evaluation of topical microbicide products in the pigtailed macaque model. J Med Primatol 41:48-51
Patton, Dorothy L; Cosgrove Sweeney, Yvonne T; Paul, Kathleen J (2008) A summary of preclinical topical microbicide vaginal safety and chlamydial efficacy evaluations in a pigtailed macaque model. Sex Transm Dis 35:889-97
Patton, D L; Cosgrove Sweeney, Y T; McCarthy, T D et al. (2006) Preclinical safety and efficacy assessments of dendrimer-based (SPL7013) microbicide gel formulations in a nonhuman primate model. Antimicrob Agents Chemother 50:1696-700
Patton, Dorothy L; Sweeney, Yvonne T Cosgrove; Balkus, Jennifer E et al. (2006) Vaginal and rectal topical microbicide development: safety and efficacy of 1.0% Savvy (C31G) in the pigtailed macaque. Sex Transm Dis 33:691-5
Patton, D L; Sweeney, Y C; Cummings, P K et al. (2004) Safety and efficacy evaluations for vaginal and rectal use of BufferGel in the macaque model. Sex Transm Dis 31:290-6