Project Start
1999-09-30
Project End
2004-09-29
Budget Start
1999-09-29
Budget End
2001-10-15
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Georgetown University
Department
Type
Other Domestic Higher Education
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Menne, Stephan; Cote, Paul J (2007) The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection. World J Gastroenterol 13:104-24
Menne, Stephan; Tennant, Bud C; Gerin, John L et al. (2007) Chemoimmunotherapy of chronic hepatitis B virus infection in the woodchuck model overcomes immunologic tolerance and restores T-cell responses to pre-S and S regions of the viral envelope protein. J Virol 81:10614-24
Menne, Stephan; Cote, Paul J; Butler, Scott D et al. (2007) Immunosuppression reactivates viral replication long after resolution of woodchuck hepatitis virus infection. Hepatology 45:614-22
Menne, Stephan; Cote, Paul J; Korba, Brent E et al. (2005) Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother 49:2720-8
Tennant, Bud C; Toshkov, Ilia A; Peek, Simon F et al. (2004) Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection. Gastroenterology 127:S283-93
Ciancio, Alessia; Smedile, Antonina; Rizzetto, Mario et al. (2004) Identification of HBV DNA sequences that are predictive of response to lamivudine therapy. Hepatology 39:64-73
Jacob, James R; Sterczer, Agnes; Toshkov, Ilia A et al. (2004) Integration of woodchuck hepatitis and N-myc rearrangement determine size and histologic grade of hepatic tumors. Hepatology 39:1008-16
Wang, Y; Jacob, J R; Menne, S et al. (2004) Interferon-gamma-associated responses to woodchuck hepatitis virus infection in neonatal woodchucks and virus-infected hepatocytes. J Viral Hepat 11:404-17
Rinaudo, Jo Ann Spiewak; Gerin, John L (2004) Cross-species hybridization: characterization of gene expression in woodchuck liver using human membrane arrays. J Med Virol 74:300-13
Jacob, James R; Korba, Brent E; Cote, Paul J et al. (2004) Suppression of lamivudine-resistant B-domain mutants by adefovir dipivoxil in the woodchuck hepatitis virus model. Antiviral Res 63:115-21

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