Abstract

The objective of the contract is to characterize the genetic basis for the expression of systemic sclerosis (Ssc). In order to accomplish this, the recurrence rate of Scleroderma within families will be established, a genome wide scan of multicase families will be performed, candidate genes will be identified, and a DNA repository (containing 800 cases and 4,600 unaffected individuals) will be established for use by other investigators. Additionally, lymphocytes from multiplex families will be frozen and stored for later establishment of cell lines to support future research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research and Development Contracts (N01)
Project #
N01AR002251-000
Application #
6359377
Study Section
Project Start
2000-09-28
Project End
2005-09-29
Budget Start
2000-09-28
Budget End
2001-09-29
Support Year
Fiscal Year
2000
Total Cost
$658,925
Indirect Cost

  Institution

Name
Wayne State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Gourh, Pravitt; Remmers, Elaine F; Boyden, Steven E et al. (2018) Brief Report: Whole-Exome Sequencing to Identify Rare Variants and Gene Networks That Increase Susceptibility to Scleroderma in African Americans. Arthritis Rheumatol 70:1654-1660
Soleimani-Meigooni, David N; Schwetye, Katherine E; Angeles, Maria Reyes et al. (2017) JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7. J Neurovirol 23:141-146
Wu, Minghua; Baron, Murray; Pedroza, Claudia et al. (2017) CCL2 in the Circulation Predicts Long-Term Progression of Interstitial Lung Disease in Patients With Early Systemic Sclerosis: Data From Two Independent Cohorts. Arthritis Rheumatol 69:1871-1878
Morgan, Nadia D; Shah, Ami A; Mayes, Maureen D et al. (2017) Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database. Medicine (Baltimore) 96:e8980
López-Isac, Elena; Martín, Jose-Ezequiel; Assassi, Shervin et al. (2016) Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies. Arthritis Rheumatol 68:2338-44
Wu, Minghua; Assassi, Shervin; Salazar, Gloria A et al. (2016) Genetic susceptibility loci of idiopathic interstitial pneumonia do not represent risk for systemic sclerosis: a case control study in Caucasian patients. Arthritis Res Ther 18:20
Salazar, Gloria; Mayes, Maureen D (2015) Genetics, Epigenetics, and Genomics of Systemic Sclerosis. Rheum Dis Clin North Am 41:345-66
Salazar, Gloria A; Assassi, Shervin; Wigley, Fredrick et al. (2015) Antinuclear antibody-negative systemic sclerosis. Semin Arthritis Rheum 44:680-6
López-Isac, Elena; Bossini-Castillo, Lara; Guerra, Sandra G et al. (2014) Identification of IL12RB1 as a novel systemic sclerosis susceptibility locus. Arthritis Rheumatol 66:3521-3
Mayes, Maureen D; Bossini-Castillo, Lara; Gorlova, Olga et al. (2014) Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. Am J Hum Genet 94:47-61

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