Furnish all necessary personnel, labor, patients, facilities, equipment, materials, and supplies required to conduct Phase II and Phase III studies in patients with disseminated solid tumors such as: cancers of the lung, breast, prostate, bladder, kidney, testicle, ovary, endometrium, cervix, head and neck, stomach, pancreas, and colon, as well as lymphomas, melanomas, and bone and soft tissue sarcomas. Seventy-five patients are required for the first four month period with 250 patients per year for the next four years. The final year of the contract is for patient treatment and follow-up only. Patients to be studied, accrued, and treated for each tumor type to be dictated by the particular protocols approved.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM007404-009
Application #
3608351
Study Section
Project Start
1980-09-15
Project End
1986-02-14
Budget Start
1984-12-31
Budget End
1986-02-14
Support Year
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Wayne State University
Department
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Tapazoglou, E; Kish, J; Ensley, J et al. (1988) Response rate and toxicity with aziridinylbenzoquinone in patients with recurrent gliomas. A progress report. Am J Clin Oncol 11:474-8
Pazdur, R; Samson, M K; Baker, L H (1987) Aclacinomycin A. Phase II evaluation in advanced soft tissue sarcoma. Am J Clin Oncol 10:237-9
Decker, D A; Kinzie, J; Evans, R et al. (1987) Pilot study of combination 5-fluorouracil, cisdiamminedichloroplatinum II, and radiation therapy for grade III and IV astrocytomas. Am J Clin Oncol 10:444-7
Pazdur, R; Samson, M K; Baker, L H (1987) Fludarabine phosphate. Phase II evaluation in advanced soft-tissue sarcomas. Am J Clin Oncol 10:341-3
Pazdur, R; Samson, M K; Baker, L H (1987) CBDCA: phase II evaluation in advanced colorectal carcinoma. Am J Clin Oncol 10:136-8
Martino, S; Decker, D A; Hynes, H E et al. (1987) Phase II evaluation of aclacinomycin-A in advanced ovarian carcinoma. Invest New Drugs 5:373-4
Al-Sarraf, M; Metch, B; Kish, J et al. (1987) Platinum analogs in recurrent and advanced head and neck cancer: a Southwest Oncology Group and Wayne State University Study. Cancer Treat Rep 71:723-6
Pazdur, R; Samson, M K; Baker, L H (1987) Aclacinomycin A. Phase II evaluation in bronchogenic squamous-cell carcinoma. Am J Clin Oncol 10:234-6
Decker, D A; Kish, J; Al-Sarraf, M et al. (1986) Phase II clinical evaluation of AZQ in renal cell carcinoma. Am J Clin Oncol 9:126-8
Kish, J A; Ensley, J; Al-Sarraf, M (1986) Phase II evaluation of diaziquone in recurrent head and neck cancer. Cancer Treat Rep 70:671-2

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