The contract will provide for the operation of a synthesis laboratory for the preparation by chemical synthesis target lead compounds. The natural products and their derivatives will be evaluated as antitumor and AIDS antiviral agents. The specific objectives are to: .optimize biological activity of natural product leads by designing and preparing by chemical synthesis analogue series which will elucidate the structure activity relationships (SAR) for that lead; .use SAR information to develop simplified more readily synthesized analogues, which may incorporate partial structures; .devise efficient synthesis routes to lead natural products or their analogues, starting from commercially available intermediates or readily purchased natural products and carry out those syntheses to afford amounts of compound required for secondary testing.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM017502-000
Application #
3609157
Study Section
Project Start
1991-05-24
Project End
1994-05-23
Budget Start
1991-05-24
Budget End
1992-05-23
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Sri International
Department
Type
DUNS #
City
Menlo Park
State
CA
Country
United States
Zip Code
94025
Ahmed, I; Jenkins, T C; Walling, J M et al. (1986) Analogues of RSU-1069: radiosensitization and toxicity in vitro and in vivo. Int J Radiat Oncol Biol Phys 12:1079-81