Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM017512-005
Application #
2299985
Study Section
Project Start
1991-09-30
Project End
1996-09-29
Budget Start
1995-08-09
Budget End
1996-09-29
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Purdue University
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Gehm, Barry D; Levenson, Anait S; Liu, Hong et al. (2004) Estrogenic effects of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors: role of AF-1 and AF-2. J Steroid Biochem Mol Biol 88:223-34
Cushman, M; He, H M; Katzenellenbogen, J A et al. (1997) Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth. J Med Chem 40:2323-34
Devraj, R; Barrett, J F; Fernandez, J A et al. (1996) Design, synthesis, and biological evaluation of ellipticine-estradiol conjugates. J Med Chem 39:3367-74
Devraj, R; Jurayj, J; Fernandez, J A et al. (1996) Synthesis of a series of cytotoxic 2-acyl-1,2-dihydroellipticines which inhibit topoisomerase II. Anticancer Drug Des 11:311-24
Cushman, M; He, H M; Katzenellenbogen, J A et al. (1995) Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site. J Med Chem 38:2041-9
Hejchman, E; Haugwitz, R D; Cushman, M (1995) Synthesis and cytotoxicity of water-soluble ambrosin prodrug candidates. J Med Chem 38:3407-10
Cushman, M; Zhu, H; Geahlen, R L et al. (1994) Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src. J Med Chem 37:3353-62
Jurayj, J; Haugwitz, R D; Varma, R K et al. (1994) Design and synthesis of ellipticinium salts and 1,2-dihydroellipticines with high selectivities against human CNS cancers in vitro. J Med Chem 37:2190-7
Cushman, M; He, H M; Lin, C M et al. (1993) Synthesis and evaluation of a series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization. J Med Chem 36:2817-21
Thakkar, K; Geahlen, R L; Cushman, M (1993) Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol. J Med Chem 36:2950-5

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