The Drug Synthesis and Chemistry Branch (DS&CB) of the Developmental Therapeutics Program (DTP) of the Division of Cancer Treatment (DCT) of the National Cancer Institute (NCI) is seeking contractors with chemical synthesis expertise to synthesis a variety of compounds for evaluation as potential anticancer agents. The objectives of this project are to: synthesize congeners of synthetic compounds with confirmed activity; design and synthesize """"""""pro-drugs"""""""" and other compounds that possess elements of both congener and pro-drug; and synthesize compounds related to products of natural origin and other related heterocycles.
Deutsch, H M; Glinski, J A; Hernandez, M et al. (1989) Synthesis of congeners and prodrugs. 3. Water-soluble prodrugs of taxol with potent antitumor activity. J Med Chem 32:788-92 |
Anderson, W K; Mach, R H (1987) Synthesis, chemical reactivity, and antileukemic activity of 5-substituted 6,7-bis(hydroxymethyl)pyrrolo[1,2-c]thiazole biscarbamates and the corresponding sulfoxides and sulfones. J Med Chem 30:2109-15 |
Deutsch, H M; Gelbaum, L T; McLaughlin, M et al. (1986) Synthesis of congeners and prodrugs of the benzene maleimide photoadduct mitindomide as potential antitumor agents. 2. J Med Chem 29:2164-70 |