Abstract

The Contractor shall furnish services, qualified personnel, material, equipment and facilities, not otherwise provided by the Government to perform assignments for Preclinical Pharmacology studies of Antitumor and Anti-HIV agents in body fluids and/or tissues of animals at know effective antitumor or antiviral concentrations. Task assignments will be issued under this Cost Reimbursement/Level of Effort contract which allows the Government to exercise control in scheduling and directing the studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM027711-008
Application #
3610230
Study Section
Project Start
1991-12-15
Project End
1994-11-14
Budget Start
1994-02-18
Budget End
1994-05-14
Support Year
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Egorin, M J; Yuan, Z M; Sentz, D L et al. (1999) Plasma pharmacokinetics of butyrate after intravenous administration of sodium butyrate or oral administration of tributyrin or sodium butyrate to mice and rats. Cancer Chemother Pharmacol 43:445-53
Egorin, M J; Rosen, D M; Benjamin, S E et al. (1997) In vitro metabolism by mouse and human liver preparations of halomon, an antitumor halogenated monoterpene. Cancer Chemother Pharmacol 41:9-14
Egorin, M J; Sentz, D L; Rosen, D M et al. (1996) Plasma pharmacokinetics, bioavailability, and tissue distribution in CD2F1 mice of halomon, an antitumor halogenated monoterpene isolated from the red algae Portieria hornemannii. Cancer Chemother Pharmacol 39:51-60
Eiseman, J L; Yuan, Z M; Eddington, N D et al. (1996) Plasma pharmacokinetics and urinary excretion of the polyamine analogue 1, 19-bis(ethylamino)-5, 10, 15-triazanonadecane in CD2F1 mice. Cancer Chemother Pharmacol 38:13-20
Eiseman, J L; Eddington, N D; Leslie, J et al. (1994) Plasma pharmacokinetics and tissue distribution of paclitaxel in CD2F1 mice. Cancer Chemother Pharmacol 34:465-71
Leslie, J; Kujawa, J M; Eddington, N et al. (1993) Stability problems with taxol in mouse plasma during analysis by liquid chromatography. J Pharm Biomed Anal 11:1349-52