Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM037818-002
Application #
2300586
Study Section
Project Start
1993-04-01
Project End
1998-01-31
Budget Start
1994-03-01
Budget End
1995-01-31
Support Year
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Southern Research Institute
Department
Type
DUNS #
006900526
City
Birmingham
State
AL
Country
United States
Zip Code
35205
Buckheit Jr, R W; White, E L; Fliakas-Boltz, V et al. (1999) Unique anti-human immunodeficiency virus activities of the nonnucleoside reverse transcriptase inhibitors calanolide A, costatolide, and dihydrocostatolide. Antimicrob Agents Chemother 43:1827-34
Buckheit Jr, R W; Hollingshead, M; Stinson, S et al. (1997) Efficacy, pharmacokinetics, and in vivo antiviral activity of UC781, a highly potent, orally bioavailable nonnucleoside reverse transcriptase inhibitor of HIV type 1. AIDS Res Hum Retroviruses 13:789-96
Kinjerski, T L; Buckheit Jr, R W (1997) The role of genotypic heterogeneity in wild type virus populations on the selection of nonnucleoside reverse transcriptase inhibitor-resistant viruses. Antiviral Res 33:109-15
Buckheit Jr, R W; Snow, M J; Fliakas-Boltz, V et al. (1997) Highly potent oxathiin carboxanilide derivatives with efficacy against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus isolates. Antimicrob Agents Chemother 41:831-7
Cushman, M; Golebiewski, W M; Graham, L et al. (1996) Synthesis and biological evaluation of certain alkenyldiarylmethanes as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors. J Med Chem 39:3217-27
Halliday, S M; Lackman-Smith, C; Bader, J P et al. (1996) Inhibition of human immunodeficiency virus replication by the sulfonated stilbene dye resobene. Antiviral Res 33:41-53
Clanton, D J; Buckheit Jr, R W; Terpening, S J et al. (1995) Novel sulfonated and phosphonated analogs of distamycin which inhibit the replication of HIV. Antiviral Res 27:335-54
Yang, S S; Fliakas-Boltz, V; Bader, J P et al. (1995) Characteristics of a group of nonnucleoside reverse transcriptase inhibitors with structural diversity and potent anti-human immunodeficiency virus activity. Leukemia 9 Suppl 1:S75-85
Buckheit Jr, R W; Fliakas-Boltz, V; Yeagy-Bargo, S et al. (1995) Resistance to 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives is generated by mutations at multiple sites in the HIV-1 reverse transcriptase. Virology 210:186-93
Buckheit Jr, R W; Kinjerski, T L; Fliakas-Boltz, V et al. (1995) Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type-1-specific compounds related to oxathiin carboxanilide. Antimicrob Agents Chemother 39:2718-27

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