Abstract

Provide DCT with a resource to select the most promising agents for clinical trial from the pool of compunds identified as active from the primary screening contracts by evaluating antitumor activity of formulated products compared to the original bulk sample.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM047580-003
Application #
3611902
Study Section
Project Start
1984-02-16
Project End
1987-02-15
Budget Start
1985-01-24
Budget End
1986-02-15
Support Year
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Southern Research Institute
Department
Type
DUNS #
006900526
City
Birmingham
State
AL
Country
United States
Zip Code
35205

  Publications

Harrison Jr, S D; Plowman, J; Dykes, D J et al. (1990) Schedule dependence, activity against natural metastases, and cross-resistance of pyrazine diazohydroxide (sodium salt, NSC 361456) in preclinical models in vivo. Cancer Chemother Pharmacol 25:425-9
Dykes, D J; Waud, W R; Harrison Jr, S D et al. (1989) Antitumor activity of 2-chloroethyl (methylsulfonyl)methanesulfonate (clomesone, NSC 33847) against selected tumor systems in mice. Cancer Res 49:1182-6
Plowman, J; Paull, K D; Atassi, G et al. (1988) Preclinical antitumor activity of batracylin (NSC 320846). Invest New Drugs 6:147-53
Plowman, J; Harrison Jr, S D; Trader, M W et al. (1987) Preclinical antitumor activity and pharmacological properties of deoxyspergualin. Cancer Res 47:685-9
Wilkoff, L J; Dulmadge, E A; Trader, M W et al. (1987) Evaluation of trans-tetrachloro-1,2-diaminocyclohexane platinum (IV) in murine leukemia L1210 resistant and sensitive to cis-diamminedichloroplatinum (II). Cancer Chemother Pharmacol 20:96-100
Harrison Jr, S D; Brockman, R W; Trader, M W et al. (1987) Cross-resistance of drug-resistant murine leukemias to deoxyspergualin (NSC 356894) in vivo. Invest New Drugs 5:345-51
Griswold Jr, D P; Trader, M W; Frei 3rd, E et al. (1987) Response of drug-sensitive and -resistant L1210 leukemias to high-dose chemotherapy. Cancer Res 47:2323-7
Shoemaker, R; Wolpert-DeFilippes, M; Plowman, J et al. (1986) Pleiotropic resistance and drug development. Prog Clin Biol Res 223:143-9
Wilkoff, L J; Dulmadge, E A (1986) Sensitivity of proliferating cultured murine pancreatic tumor cells to selected antitumor agents. J Natl Cancer Inst 77:1163-9
Harrison Jr, S D; O'Dwyer, P J; Trader, M W (1986) Therapeutic synergism of tiazofurin and selected antitumor drugs against sensitive and resistant P388 leukemia in mice. Cancer Res 46:3396-400

Showing the most recent 10 out of 11 publications