The specific objectives of this project are to design and synthesize the following: 1. Congeners of lead compounds having confirmed activity, to enhance activity or potency. 2. Prodrugs with structural modifications that may provide improved pharmacokinetics, altered drug transport, improved bio-availability through increased water solubility, or increased chemical stability. 3. Other altered structures that possess elements of both congener and prodrug. Modifications of a lead may also include partial structures. 4. Compounds related to natural products, e.g., such as alkaloids, heterocycles, nucleosides, peptides.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM067261-008
Application #
6316173
Study Section
Project Start
1996-09-30
Project End
2000-03-31
Budget Start
2000-05-23
Budget End
2000-03-31
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Tennessee Knoxville
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Knoxville
State
TN
Country
United States
Zip Code
37996