Dosage Forms/Delivery System for New Antitumor Agents

Stella, Valentino J.

Abstract

The primary purpose of this project is to provide long range fundamental studies of compounds which exhibit inadequate solubility and/or stability and are not suitable or responsive to simple solvent of parenteral dosage forms of potentially active antitumor agents, and more effective approaches for the intravenous delivery of compounds that posses limited solubility and/or stability.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Division of Cancer Treatment (NCI)
• Type: Research and Development Contracts (N01)
• Project #: N01CM097576-001
• Application #: 3616702
• Project Start: 1989-06-30
• Project End: 1992-06-29
• Budget Start: 1990-06-30
• Budget End: 1991-06-29
• Fiscal Year: 1990

Institution

• Name: University of Kansas Lawrence
• Type: Schools of Pharmacy
• DUNS #: 072933393
• City: Lawrence
• State: KS
• Country: United States
• Zip Code: 66045

Publications

Scott, D O; Bindra, D S; Sutton, S C et al. (1994) Urinary and biliary disposition of the lactone and carboxylate forms of 20(S)-camptothecin in rats. Drug Metab Dispos 22:438-42

Bindra, D S; Williams, T D; Stella, V J (1994) Degradation of O6-benzylguanine in aqueous polyethylene glycol 400 (PEG 400) solutions: concerns with formaldehyde in PEG 400. Pharm Res 11:1060-4

Scott, D O; Bindra, D S; Stella, V J (1993) Plasma pharmacokinetics of lactone and carboxylate forms of 20(S)-camptothecin in anesthetized rats. Pharm Res 10:1451-7

Fassberg, J; Stella, V J (1992) A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues. J Pharm Sci 81:676-84

Mathew, A E; Mejillano, M R; Nath, J P et al. (1992) Synthesis and evaluation of some water-soluble prodrugs and derivatives of taxol with antitumor activity. J Med Chem 35:145-51

Waugh, W N; Trissel, L A; Stella, V J (1991) Stability, compatibility, and plasticizer extraction of taxol (NSC-125973) injection diluted in infusion solutions and stored in various containers. Am J Hosp Pharm 48:1520-4