The objective of this study is to determine whether a diet containing toasted soybean meal and licorice root extract can modulate key regulatory biochemical pathways in animals. Seven groups of 24 male rats will be fed a control diet, 3.0, 1.5, and 0.38% (w/w) licorice root extract or 25.0, 12.5, and 3.13% (w/w) toasted soybean meal individually or in combination for two months. Blood, liver, adrenals, testes, kidneys, and intestines will be obtained.Histology specimens of each organ will be evaluated. Assays will include glucose-6-phosphate dehydrogenase, catalase, glutathione peroxidase, glutathione reductase, glutathione transferase, xanthin oxidase, UDPG transferase, ornithine decarboxylase, cytochrome P isoenzymes, cAMP, cGMP levels protein kinase, urinary and fecal total nitrogen.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Prevention And Control (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CN005261-001
Application #
3617160
Study Section
Project Start
1990-11-30
Project End
Budget Start
1990-11-30
Budget End
1991-09-29
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Ohio State University
Department
Type
Schools of Pharmacy
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210