Chemoprevention of Dmba-Induced Mammary Tumors in the

Grubbs, Clinton J.

Abstract

The main objective of this Master Agreement is to evaluate inhibitors or potential inhibitors of any stage of carcinogenesis in whole animal models where cancer is induced. In this Master Agreement order the purpose is to identify combinations of compounds which inhibit methyl-nitrosourea induced mammary cancer in female rats.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Division of Cancer Prevention And Control (NCI)
• Type: Research and Development Contracts (N01)
• Project #: N01CN025454-002
• Application #: 3617826
• Project Start: 1992-10-31
• Budget Start: 1992-10-31
• Budget End: 1994-10-30
• Fiscal Year: 1993

Institution

• Name: University of Alabama Birmingham
• Type: Schools of Allied Health Profes
• DUNS #: 004514360
• City: Birmingham
• State: AL
• Country: United States
• Zip Code: 35294

Publications

Rodriguez-Burford, C; Lubet, R A; Eto, I et al. (1999) Effect of reduced body weight gain on the evaluation of chemopreventive agents in the methylnitrosourea-induced mammary cancer model. Carcinogenesis 20:71-6

Lubet, R A; Steele, V E; Eto, I et al. (1997) Chemopreventive efficacy of anethole trithione, N-acetyl-L-cysteine, miconazole and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model. Int J Cancer 72:95-101

Pereira, M A; Grubbs, C J; Barnes, L H et al. (1996) Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbenz[a]anthracene-induced mammary cancer in rats. Carcinogenesis 17:1305-11