The objective of this workstatement is to investigate the efficacy of a variety of potential chemopreventive agents in that MNU-induced rat mammary tumor model. This model which entails injection of MNU into 50 day old rats results in tumors with many of the same properties (histopathologic, endocrinologic, response to known therapeutic and chemopreventive agents) that are typical of the human disease. This model will e used to examine a number of potential chemopreventive agents including aromatase inhibitors, differentiating agents, specific inhibitors of prostaglandin synthesis, etc. Agents which are highly effective in these models will be further investigated with respect to their biologic and toxicologic properties and advanced into clinical testing if these initial results appear promising.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Prevention And Control (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CN075101-000
Application #
2600142
Study Section
Project Start
1997-06-30
Project End
Budget Start
1997-06-30
Budget End
1999-06-30
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Nutrition
Type
Schools of Allied Health Profes
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Rodriguez-Burford, Cristina; Steele, Vernon E; Anderson, Amy S et al. (2002) Effects of body weight gain reduction resulting from chemopreventive agent treatment on mammary gland morphology. Nutr Cancer 43:67-75
Rodriguez-Burford, C; Lubet, R A; Steele, V E et al. (2001) Effects of acute and chronic body weight gain reductions in the evaluation of agents for efficacy in mammary cancer prevention. Oncol Rep 8:373-9