Abstract

The objectives of this project are to describe and evaluate the determinants of gastric dysplasia and chronic atrophic gastritis, conditions thought to be precursors to stomach cancer, in a population in Shandong, China where stomach cancer rates are high. This will be accomplished by a population-based endoscopic survey of 3,000 adults age 35-64 to classify gastric status, with information on diet, tobacco consumption, medical history and other exposures obtained via interviews and measurements of nutrients and other substances in blood, urine, and gastric juice. Rates of transitions of these gastric lesions to cancer will be determined via follow-up of the study population over a 6-year period.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP015620-000
Application #
3627028
Study Section
Project Start
1991-02-10
Project End
Budget Start
1991-02-10
Budget End
1992-02-09
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Beijing Institute for Cancer Research
Department
Type
DUNS #
City
Beijing
State
Country
China
Zip Code

  Publications

Riecken, B; Pfeiffer, R; Ma, J L et al. (2002) No impact of repeated endoscopic screens on gastric cancer mortality in a prospectively followed Chinese population at high risk. Prev Med 34:22-8
You, W C; Zhang, L; Pan, K F et al. (2001) Helicobacter pylori prevalence and CagA status among children in two counties of China with high and low risks of gastric cancer. Ann Epidemiol 11:543-6
You, W C; Ma, J L; Liu, W et al. (2000) Blood type and family cancer history in relation to precancerous gastric lesions. Int J Epidemiol 29:405-7
You, W C; Li, J Y; Blot, W J et al. (1999) Evolution of precancerous lesions in a rural Chinese population at high risk of gastric cancer. Int J Cancer 83:615-9
You, W C; Zhang, L; Gail, M H et al. (1998) Precancerous lesions in two counties of China with contrasting gastric cancer risk. Int J Epidemiol 27:945-8
Ma, J L; You, W C; Gail, M H et al. (1998) Helicobacter pylori infection and mode of transmission in a population at high risk of stomach cancer. Int J Epidemiol 27:570-3
You, W C; Zhang, L; Gail, M H et al. (1998) Helicobacter pylori infection, garlic intake and precancerous lesions in a Chinese population at low risk of gastric cancer. Int J Epidemiol 27:941-4
You, W C; Zhang, L; Yang, C S et al. (1996) Nitrite, N-nitroso compounds, and other analytes in physiological fluids in relation to precancerous gastric lesions. Cancer Epidemiol Biomarkers Prev 5:47-52
Zhao, L; Blot, W J; Liu, W D et al. (1994) Familial predisposition to precancerous gastric lesions in a high-risk area of China. Cancer Epidemiol Biomarkers Prev 3:461-4
Zhang, L; Blot, W J; You, W C et al. (1994) Serum micronutrients in relation to pre-cancerous gastric lesions. Int J Cancer 56:650-4

Showing the most recent 10 out of 13 publications