The proposed project involves a collaboration with the Gorgas Memorial Laboratory in Panama City, Panama. The Gorgas Memorial Laboratory will supply support to this project by assisting in collecting samples on patients with various malignancies suspected to be linked to HTLV and from corresponding normal populations. Studies will be undertaken to determine the distribution of HTLV infection in Panama to see whether virus clusters occur in regions of the County and within households. In addition, serum will be collected prospectively on various other high-risk populations such as close family members of cases. Finally, case-control strategies will be developed where appropriate to define the risk factors associated with HTLV infection and leukemia. The epidemiologic guidance for this project will come from the Principal Investigator and the Environmental Epidemiology Branch of the National Cancer Institute. Personnel to implement the epidemiologic components of this project will be supplied by the proposed contractor.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP031015-009
Application #
3628017
Study Section
Project Start
1983-09-30
Project End
1990-06-30
Budget Start
1989-03-24
Budget End
1990-06-30
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Gorgas Memorial Institute of Trop & Prev Med
Department
Type
DUNS #
City
Bethesda
State
MD
Country
United States
Zip Code
20814
Reeves, W C; Levine, P H; Cuevas, M et al. (1990) Seroepidemiology of human T cell lymphotropic virus in the Republic of Panama. Am J Trop Med Hyg 42:374-9
Gracia, F; Reeves, W C; Levine, P H et al. (1990) Human T-cell lymphotropic virus type I and neurologic disease in Panama, 1985 and 1986. Arch Neurol 47:634-9
Levine, P H; Reeves, W C; Cuevas, M et al. (1989) Human T-cell leukemia virus-I and hematologic malignancies in Panama. Cancer 63:2186-91
Reeves, W C; Cuevas, M; Arosemena, J R et al. (1988) Human immunodeficiency virus infection in the Republic of Panama. Am J Trop Med Hyg 39:398-405
Reeves, W C; Saxinger, C; Brenes, M M et al. (1988) Human T-cell lymphotropic virus type I (HTLV-I) seroepidemiology and risk factors in metropolitan Panama. Am J Epidemiol 127:532-9