Produce, characterize, and provide monoclonal and monospecific antibodies to the protein oncogene products of avian and mammalian retroviruses. The monoclonal antibodies will be directed against the amino and carboxy terminal ends of the oncogene and the active site. The antigens used will be synthetic peptides which are identical in sequence to the native oncogene products, but considerably smaller in size. This contract will operate under the payback system for cost reimbursement, but total cost recovery is not anticipated.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP041009-004
Application #
3629552
Study Section
Project Start
1984-09-30
Project End
1987-09-29
Budget Start
1986-09-30
Budget End
1987-09-29
Support Year
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92037
Niman, H L (1989) Monoclonal antibodies to oncogene products. Prog Clin Biol Res 288:35-52
Chesa, P G; Rettig, W J; Melamed, M R et al. (1987) Expression of p21ras in normal and malignant human tissues: lack of association with proliferation and malignancy. Proc Natl Acad Sci U S A 84:3234-8
Niman, H L (1986) Human oncogene-related proteins in urine during pregnancy and neoplasia. Clin Lab Med 6:181-96
Niman, H L; Thompson, A M; Yu, A et al. (1985) Anti-peptide antibodies detect oncogene-related proteins in urine. Proc Natl Acad Sci U S A 82:7924-8