Toxicology and Pharmacology of Anticarcinogenic Agents

McCormick, David L.

Abstract

Expedite the development of new anticarcinogenic agents. These studies will be linked in large measure to other projects in biological and chemical prevention of carcinogenesis programs, which will provide the agents to be investigated and the means for testing agents for efficacy in anticarcinogenesis.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Division of Cancer Epidemiology And Genetics (NCI)
• Type: Research and Development Contracts (N01)
• Project #: N01CP041063-002
• Application #: 3629681
• Project Start: 1984-09-30
• Project End: 1988-09-29
• Budget Start: 1985-06-04
• Budget End: 1986-09-29
• Fiscal Year: 1985

Institution

• Name: Iit Research Institute
• DUNS #: 005447826
• City: Chicago
• State: IL
• Country: United States
• Zip Code: 60616

Publications

McCormick, D L; Hollister, J L; Bagg, B J et al. (1990) Enhancement of murine hepatocarcinogenesis by all-trans-retinoic acid and two synthetic retinamides. Carcinogenesis 11:1605-9

Hultin, T A; Filla, M S; McCormick, D L (1990) Distribution and metabolism of the retinoid, N-(4-methoxyphenyl)-all-trans-retinamide, the major metabolite of N-(4-hydroxyphenyl)-all-trans-retinamide, in female mice. Drug Metab Dispos 18:175-9

Hultin, T A; McCormick, D L; May, C M et al. (1988) Effects of pretreatment with the retinoid N-(4-hydroxyphenyl)-all-trans-retinamide and phenobarbital on the disposition and metabolism of N-(4-hydroxyphenyl)-all-trans-retinamide in mice. Drug Metab Dispos 16:783-8

McCormick, D L; Hultin, T A; Detrisac, C J (1987) Potentiation of vitamin A hepatotoxicity by butylated hydroxytoluene. Toxicol Appl Pharmacol 90:1-9

McCormick, D L; Bagg, B J; Hultin, T A (1987) Comparative activity of dietary or topical exposure to three retinoids in the promotion of skin tumor induction in mice. Cancer Res 47:5989-93

McCormick, D L; Moon, R C (1986) Antipromotional activity of dietary N-(4-hydroxyphenyl)retinamide in two-stage skin tumorigenesis in CD-1 and SENCAR mice. Cancer Lett 31:133-8

McCormick, D L; Wilson, A M (1986) Combination chemoprevention of rat mammary carcinogenesis by indomethacin and butylated hydroxytoluene. Cancer Res 46:3907-11