Abstract

The Occupational Studies Section (OSS), Environmental Epidemiology Branch (EEB), Epidemiology & Biostatistics Program (EBP), Division of Cancer Etiology (DCE), National Cancer Institute (NCI) and the National Institute for Occupational Safety and Health (NIOSH) are collaborating to develop a user friendly, flexible, computerized system for documentation of descriptive data and for development of quantitative estimates of occupational cohort studies. The purpose of this contract is to convert the computerized exposure assessment system developed for the acrylonitrile study into a more user friendly, flexible, system for documentation of descriptive data and for development of quantitative estimates of occupational cohort studies. The requirements of the system would be that it be adaptable to a wide variety of epidemiologic investigations and that it incorporate both quantitative and qualitative information on exposures. The estimation methods would incorporate a few standardized algorithms, but would be designed to allow users to develop their own estimation procedures.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP051013-000
Application #
3630872
Study Section
Project Start
1984-11-01
Project End
1989-10-31
Budget Start
1984-11-01
Budget End
1985-10-31
Support Year
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Covance Laboratories, Inc.
Department
Type
DUNS #
City
Vienna
State
VA
Country
United States
Zip Code
22182

  Publications

Snyderwine, E G; Turesky, R J; Turteltaub, K W et al. (1997) Metabolism of food-derived heterocyclic amines in nonhuman primates. Mutat Res 376:203-10
Thorgeirsson, U P; Gomez, D E; Lindsay, C K et al. (1996) Liver tumors and possible preneoplastic lesions, induced by a food-derived heterocyclic amine in cynomolgus monkeys;a study of histology and cytokeratin expression. Liver 16:71-83
Thorgeirsson, U P; Snyderwine, E G; Gomez, D E et al. (1996) Dietary heterocyclic amines as potential human carcinogens: experimental data from nonhuman primates. In Vivo 10:145-52
Dalgard, D W; Thorgeirsson, U P; Adamson, R H (1995) Laparoscopy as a means of monitoring liver tumor induction in nonhuman primates. Princess Takamatsu Symp 23:268-73
Snyderwine, E G; Turesky, R J; Buonarati, M H et al. (1995) Metabolic processing and disposition of 2-amino-3-methylimidazo[4,5-f] quinoline (IQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in nonhuman primates. Princess Takamatsu Symp 23:69-77
Adamson, R H; Takayama, S; Sugimura, T et al. (1994) Induction of hepatocellular carcinoma in nonhuman primates by the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline. Environ Health Perspect 102:190-3
Thorgeirsson, U P; Farb, A; Virmani, R et al. (1994) Cardiac damage induced by 2-amino-3-methyl-imidazo[4,5-f]quinoline in nonhuman primates. Environ Health Perspect 102:194-9
Davis, C D; Schut, H A; Adamson, R H et al. (1993) Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo. Carcinogenesis 14:61-5
Snyderwine, E G; Schut, H A; Adamson, R H et al. (1992) Metabolic activation and genotoxicity of heterocyclic arylamines. Cancer Res 52:2099s-2102s
Snyderwine, E G; Welti, D H; Fay, L B et al. (1992) Metabolism of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates undergoing carcinogen bioassay. Chem Res Toxicol 5:843-51

Showing the most recent 10 out of 14 publications