The goal of this project is the synthesis, purification and characterization of selected derivatives (primarily oxygenated derivatives) of polynuclear aromatic hydrocarbons in gram quantities. The types of compounds include dihydrodiols; phenols; quinones; diolepoxides; epoxides; dialdehydes resulting from cleavage of cicinally-dissubstituted oxygenated derivatives; alkyl and hydroxyalkyl-substituted parent hydrocarbons; conjugated derivatives (chemical or biosynthetic) such as gluthathiones, glucuronides, and sulfates; and labeled (3H, 13C, 14C) analogs. The compounds are required in carcinogenesis research as authentic standards and substrates to aid in the elucidation of the pathways or carcinogen metabolism, activation, and molecular mechanism of action.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP061037-000
Application #
3632087
Study Section
Project Start
1986-06-18
Project End
1991-03-31
Budget Start
1986-06-18
Budget End
1987-03-31
Support Year
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Chemsyn Science Laboratories
Department
Type
DUNS #
City
Lenexa
State
KS
Country
United States
Zip Code
66215