The objective of this contract is to obtain information regarding abuse potential of various drugs by intravenous and oral routes of administration in laboratory primates. Specifically the contractor will be asked to focus on generating data pertaining to relative abuse potential of self-administered pharmacological agents by means of sophisticated and sensitive laboratory methods to assess relative abuse liability of compounds both within and between drug classes. These data are needed to fulfill, at least in part, the National Institute on Drug Abuse statutory obligation to generate information concerning abuse potential of drugs for the Department of Health and Human Services (HHS). The data generated will be used by the Food and Drug Administration (FDA) and the Drug Enforcement Administration (DEA) for making recommendations and decisions, respectively, pertaining to scheduling of drugs under the Controlled Substances Act of 1970 (PL 91-513) and international drug control treaties (Single Convention and the Psychotropic Convention).

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research and Development Contracts (N01)
Project #
N01DA057050-000
Application #
2306478
Study Section
Project Start
1995-09-28
Project End
1998-09-27
Budget Start
1995-09-28
Budget End
1996-09-27
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Ator, Nancy A; Griffiths, Roland R; Weerts, Elise M (2005) Self-injection of flunitrazepam alone and in the context of methadone maintenance in baboons. Drug Alcohol Depend 78:113-23
Weerts, E M; Griffiths, R R (1999) Evaluation of the intravenous reinforcing effects of clonidine in baboons. Drug Alcohol Depend 53:207-14
Weerts, E M; Ator, N A; Griffiths, R R (1999) Comparison of the intravenous reinforcing effects of propofol and methohexital in baboons. Drug Alcohol Depend 57:51-60