One of NIDA's primary program objectives is to stimulate and support research on drugs of abuse in the areas of pharmacokinetics, metabolism, pharmacology and toxicology. It is essential to identify and to quantify drugs and their metabolites in biological fluids such as cannabinoids, opiates, amphetamines, l-alpha-acetyl-methadol (LAAM), naltrexone, methadone, cocaine, phencyclidine, anabolic steroids, opioid peptides and peptidomimetics, anadamides and their metabolites, and benzodiazepines. These usually appear in biological material at concentrations of ng/g or ng/ml and therefore require the use of state of the art chromatography methods including gas chronography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). Since 1974, the National Institute on Drug Abuse has been providing analytical support to investigators in the drug abuse area for whom this analytical methodology is not available otherwise. This contract is to continue this analytical service and also to serve as a reference laboratory by which new methodologies currently under development can be assessed and validated. The contractor shall quantify a variety of drugs and their metabolites in biological fluids including plasma, urine, saliva and various tissues. The analytical methodology shall provide sensitivity and specificity for analysis of drugs for pharmacokinetic studies, usually in ng/ml or ng/g range. In the case of LSD, sensitivity of 100pg in urine or blood.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research and Development Contracts (N01)
Project #
N01DA067052-002
Application #
2420219
Study Section
Project Start
1995-12-15
Project End
2000-12-14
Budget Start
1996-12-13
Budget End
1997-12-14
Support Year
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Utah
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Wansaw, Michael P; Lin, Shen-Nan; Morrell, Joan I (2005) Plasma cocaine levels, metabolites, and locomotor activity after subcutaneous cocaine injection are stable across the postpartum period in rats. Pharmacol Biochem Behav 82:55-66
Festa, Eugene D; Russo, Scott J; Gazi, Farhad M et al. (2004) Sex differences in cocaine-induced behavioral responses, pharmacokinetics, and monoamine levels. Neuropharmacology 46:672-87
Williams, Michael T; Brown, Carrie A; Skelton, Matthew R et al. (2004) Absorption and clearance of +/-3,4-methylenedioxymethamphetamine from the plasma of neonatal rats. Neurotoxicol Teratol 26:849-56
Lin, Shen-Nan; Walsh, Sharon L; Moody, David E et al. (2003) Detection and time course of cocaine N-oxide and other cocaine metabolites in human plasma by liquid chromatography/tandem mass spectrometry. Anal Chem 75:4335-40