Abstract

The purpose of this contract is to identify inbred strains of mice with profound, early-onset, inherited hearing impairment, and to determine the chromosomal localization of the affected mouse gene in these strains.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research and Development Contracts (N01)
Project #
N01DC062108-007
Application #
6159890
Study Section
Project Start
1996-06-17
Project End
2003-06-30
Budget Start
1999-10-06
Budget End
2000-06-30
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609

  Publications

Odeh, Hana; Hunker, Kristina L; Belyantseva, Inna A et al. (2010) Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse. Am J Hum Genet 86:148-60
Karolyi, I Jill; Dootz, Gary A; Halsey, Karin et al. (2007) Dietary thyroid hormone replacement ameliorates hearing deficits in hypothyroid mice. Mamm Genome 18:596-608
Zheng, Q Y; Johnson, K R; Erway, L C (1999) Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hear Res 130:94-107
Noben-Trauth, K; Zheng, Q Y; Johnson, K R et al. (1997) mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw). Genomics 44:266-72