Abstract

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to maintain the Liver Tissue Procurement and Distribution System (LTPADS) as a network of three geographically distributed Tissue Collection Centers. The LTPADS shall serve as a resource for investigators to obtain human liver tissue for scientific investigations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research and Development Contracts (N01)
Project #
N01DK092310-001
Application #
6216372
Study Section
Project Start
1999-02-01
Project End
2003-12-31
Budget Start
2000-01-12
Budget End
2000-12-31
Support Year
Fiscal Year
2000
Total Cost
$488,472
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Pediatrics
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Fang, H; Liu, X; Ramírez, J et al. (2014) Establishment of CYP2D6 reference samples by multiple validated genotyping platforms. Pharmacogenomics J 14:564-72
Thangavel, Chellappagounder; Boopathi, Ettickan; Shapiro, Bernard H (2013) Inherent sex-dependent regulation of human hepatic CYP3A5. Br J Pharmacol 168:988-1000
Noreault-Conti, Trisha L; Fellows, Abigail; Jacobs, Judith M et al. (2012) Arsenic decreases RXR?-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes. Int Immunopharmacol 12:651-6
Ross, Matthew K; Borazjani, Abdolsamad; Wang, Ran et al. (2012) Examination of the carboxylesterase phenotype in human liver. Arch Biochem Biophys 522:44-56
Anderson, Linnea E; Dring, Ann M; Hamel, Laura D et al. (2011) Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR). Toxicol Lett 202:148-54
Singh, Rashmi; Bullard, Jay; Kalra, Mamta et al. (2011) Status of bacterial colonization, Toll-like receptor expression and nuclear factor-kappa B activation in normal and diseased human livers. Clin Immunol 138:41-9
Chaudhry, Amarjit S; Urban, Thomas J; Lamba, Jatinder K et al. (2010) CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose. J Pharmacol Exp Ther 332:599-611
Han, Shuxin; Li, Tiangang; Ellis, Ewa et al. (2010) A novel bile acid-activated vitamin D receptor signaling in human hepatocytes. Mol Endocrinol 24:1151-64
Yang, Xia; Zhang, Bin; Molony, Cliona et al. (2010) Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res 20:1020-36
Song, Kwang-Hoon; Li, Tiangang; Owsley, Erika et al. (2009) Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. Hepatology 49:297-305

Showing the most recent 10 out of 65 publications