Abstract

The Virology Laboratory (VL) shall serve as the central laboratory for hepatitis C virus testing as well as a central repository for serum and liver tissue from patients participating in the study. The VL shall provide expert advice regarding virological testing and how results can provide further insights into the natural history of hepatitis C and the effects of interferon therapy. The VL shall work actively with the Steering Committee of the Trial to apply new molecular approaches to the study of patients with chronic hepatitis C participating in this Trial. The VL shall thus provide uniform, efficient and high quality virologicial testing and interpretation in support of the Trial.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research and Development Contracts (N01)
Project #
N01DK092318-000
Application #
6077033
Study Section
Project Start
1999-05-01
Project End
2007-04-30
Budget Start
1999-05-01
Budget End
2000-04-30
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Pathology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Wang, Weihua; Zhang, Xiaoan; Xu, Yanjuan et al. (2014) High-resolution quantification of hepatitis C virus genome-wide mutation load and its correlation with the outcome of peginterferon-alpha2a and ribavirin combination therapy. PLoS One 9:e100131
Paralkar, Vikram R; Mishra, Tejaswini; Luan, Jing et al. (2014) Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development. Blood 123:1927-37
Snow, Kristin K; Bell, Margaret C; Stoddard, Anne M et al. (2014) Processes to manage analyses and publications in a phase III multicenter randomized clinical trial. Trials 15:159
Everhart, James E; Wright, Elizabeth C (2013) Association of ?-glutamyl transferase (GGT) activity with treatment and clinical outcomes in chronic hepatitis C (HCV). Hepatology 57:1725-33
Sterling, Richard K; Wright, Elizabeth C; Morgan, Timothy R et al. (2012) Frequency of elevated hepatocellular carcinoma (HCC) biomarkers in patients with advanced hepatitis C. Am J Gastroenterol 107:64-74
Morishima, C; Di Bisceglie, A M; Rothman, A L et al. (2012) Antigen-specific T lymphocyte proliferation decreases over time in advanced chronic hepatitis C. J Viral Hepat 19:404-13
Corey, Kathleen E; Zheng, Hui; Mendez-Navarro, Jorge et al. (2012) Serum vitamin D levels are not predictive of the progression of chronic liver disease in hepatitis C patients with advanced fibrosis. PLoS One 7:e27144
Morishima, Chihiro; Shiffman, Mitchell L; Dienstag, Jules L et al. (2012) Reduction in Hepatic Inflammation Is Associated With Less Fibrosis Progression and Fewer Clinical Outcomes in Advanced Hepatitis C. Am J Gastroenterol 107:1388-98
Abu Dayyeh, Barham K; Yang, May; Fuchs, Bryan C et al. (2011) A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma. Gastroenterology 141:141-9
Hoefs, John C; Shiffman, Mitchell L; Goodman, Zachary D et al. (2011) Rate of progression of hepatic fibrosis in patients with chronic hepatitis C: results from the HALT-C Trial. Gastroenterology 141:900-908.e1-2

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