Phenolphthalein is widely used as a cathartic and is the basis for many laxatives. Phenolphthalein was nominated for further toxicity and carcinogenicity studies in rodents because adequate studies had not previously been performed, and significant numbers of people are exposed to this compound through its use as a laxative. The objective of this contract is to administer the compound in the feed to F344/N rats and B6C3F1 mice for two years, and to examine tissues and organs for the presence of treatment-related non-neoplastic or neoplastic lesions.

Project Start
1990-08-10
Project End
1993-11-10
Budget Start
1991-05-22
Budget End
1992-08-09
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Tsi Mason Laboratories
Department
Type
DUNS #
City
Worcester
State
MA
Country
United States
Zip Code
01608