This project plan is for the supplemental support of chemistry activities of the toxicology contractors as well as to provide chemistry support for the staff research activities of the Chemical Carcinogenesis Branch. The resources of the chemistry support contractor will be used to: 1) procure difficult to obtain test chemicals prior to issuance of a Request For Proposals to ensure that a toxicology study can be conducted; 2) provide special handling of the bulk chemicals such as purification or particle size reduction that may be needed prior to use in dose formulations; 3) identify low level impurities that may have an impact on the evaluation of the carcinogenesis study results; 4) generate information for some test chemicals to assist in study design such as stability in the proposed dose vehicle or the maximum concentration in the vehicle that can be achieved; 5) evaluate and resolve analytical problems encountered by the toxicology contractors and 6) provide chemistry support for in-house studies including analysis of test article or metabolites in tissues or biological fluids.

Project Start
1990-12-10
Project End
1996-01-15
Budget Start
1990-12-10
Budget End
1991-11-30
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Midwest Research Institute
Department
Type
DUNS #
007173453
City
Kansas City
State
MO
Country
United States
Zip Code
64110