The objective of this contract is to provide methods development and testing capacity that will permit the Cellular and Genetic Toxicology Branch to continue its improvement, assessment and application of short term, in vivo tests for genetic toxicity. This award will include projects involving tests for micronuclei, chromosomal aberrations and sister- chromatoid exchanges in mice and the development of testing capabilities in rats. Tests are conducted using, primarily, the bone marrow cells. Test results from these studies are used in the process of selecting chemicals for long term toxicity tests, by the Toxicology Research and Design Committee, in the overall evaluation of long term toxicity studies, and in the selection of chemicals for germ cell mutagenicity studies.

Project Start
1991-02-15
Project End
1996-02-14
Budget Start
1992-01-07
Budget End
1993-02-14
Support Year
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Integrated Laboratory Systems, Inc.
Department
Type
DUNS #
City
Research Triangle Park
State
NC
Country
United States
Zip Code
27709