The purpose of this contract is to provide clinical research support services for researchers in the NIEHS Division of Intramural Research. The contract is a ten year, level of effort, term form task order contract. Tasks included at award are: (1.) Administrative Core Task providing for administration of the contract and preparation of clinical task proposals; (2.) Training of Physicians and Nurses, a ten year task providing for training physicians and nurses in environmental medicine including basic research activities in NIEHS Division of Intramural Research laboratories; (3.) Role of Environmental Estrogens on Puberty, a four year task supporting NIEHS DIR research into the affects of exposure to estrogens and estrogenic substances on the early onset and progression of puberty and other body functions that may be related to exposure to sex steroids. It is anticipated that one clinical research task will be added to the contract each year through year eight with an estimated total of 11 to 12 tasks awarded during the contract period of performance.

Project Start
1993-06-30
Project End
2003-06-29
Budget Start
1995-06-21
Budget End
1996-06-29
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Alexis, Neil E; Eldridge, Marlowe W; Peden, David B (2003) Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11b expression in atopic asthmatic subjects. J Allergy Clin Immunol 112:353-61
Robbins, W A; Witt, K L; Haseman, J K et al. (2001) Antiretroviral therapy effects on genetic and morphologic end points in lymphocytes and sperm of men with human immunodeficiency virus infection. J Infect Dis 184:127-35
Eldridge, M W; Peden, D B (2000) Allergen provocation augments endotoxin-induced nasal inflammation in subjects with atopic asthma. J Allergy Clin Immunol 105:475-81
Eldridge, M W; Peden, D B (2000) Airway response to concomitant exposure with endotoxin and allergen in atopic asthmatics. J Toxicol Environ Health A 61:27-37
Coffey, C S; Muller, K E (1999) Exact test size and power of a Gaussian error linear model for an internal pilot study. Stat Med 18:1199-214
Shea, K M; Little, R E (1997) Is there an association between preconception paternal x-ray exposure and birth outcome? The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Am J Epidemiol 145:546-51
Shea, K M; Farrow, A; Little, R (1997) An investigation of the effect of paternal occupation group at conception on birth weight and gestational age. ALSPAC Study Team of Pregnancy and Childhood. Am J Ind Med 31:738-43
Warshauer, D M; Wehmueller, M D; Molina, P L et al. (1997) Hepatic enhancement and metastatic lesion conspicuity on CT scans: influence of intravenous glucagon and oral CT contrast material. Radiology 202:394-8
Zeldin, D C; Foley, J; Ma, J et al. (1996) CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance. Mol Pharmacol 50:1111-7