Abstract

The purpose of the contract is to test 10 chemicals per year for mutagenicity using the Drosophila sex-linked recessive lethal assay. This assay is an in vivo test for germ cell mutation. Chemicals will be administered first by feeding. If the result is negative, the chemical will be administered by injection and retested. If the result is positive in either test for recessive lethals, the chemical will be tested in the assay for reciprocal translocations using the route administration that gave the positive result. The chemicals will be chosen based on an interest in the results of the two year assay for carcinogenesis or the mouse germ cell mutagenesis assays.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research and Development Contracts (N01)
Project #
N01ES075182-000
Application #
3641925
Study Section
Project Start
1987-09-30
Project End
1991-09-29
Budget Start
1987-09-30
Budget End
1988-09-29
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715