The objective of this project is to characterize dose-response relationships and toxicity of dipropylene glycol administered by dosed- water to rats and mice in 14-day repeated-dose and 90-day subchronic studies. At the end of each study, all animals will be given gross and microscopic histopathologic evaluations. Hematology, clinical chemistry, urinalysis, and sperm morphology/vaginal cytology will be performed in the 90-day study. The results of each study will be used by NTP to establish doses to be used in the next study (i.e., the 14-day results for the 90-day study; the 90-day results for a possible chronic study).

Project Start
1989-09-15
Project End
Budget Start
1989-09-15
Budget End
1991-05-14
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Arthur D. Little, Inc.
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02140