Prechronic and chronic toxicology and carcinogenicity studies of Acetaminophen (4-Hydroxyacetanilide) and Turmeric, oleoresin feed studies were conducted in Fischer 344/N rats and B6C3F1 mice. The purpose of the prechronic studies was to determine the toxicity of the chemical by a given route of administration, in order to determine the maximum tolerated dose, the slope of the dose-response curve, and potential target organ(s) for the two-year chronic studies. The two-year chronic feed studies were performed in order to determine the long-term effects of the subject chemical in these species.

Project Start
1980-08-29
Project End
1987-04-30
Budget Start
1986-07-10
Budget End
1987-04-30
Support Year
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Tsi Mason Laboratories
Department
Type
DUNS #
City
Worcester
State
MA
Country
United States
Zip Code
01608