Abstract

The contractor shall maintain a colony of fifty-one (51) chimpanzees to be utilized in non-destructive experiments judged most likely to advance hepatitis or acquired immunodeficiency syndrome (AIDS) research. A major emphasis of research will be on hepatitis C virus (HCV) since this form of liver disease is responsible for over 90 percent of transfusion-transmitted hepatitis cases in the United States. Since the chimpanzee is the only animal susceptible to this human disease, the NHLBI colony may be used in research to characterize the virus and in efforts to develop an HCV vaccine. Another major focus will be on acquired immunodeficiency syndrome (AIDS) research. The causative agent, human immunodeficiency virus (HIV), can be readily transmitted from humans to chimpanzees. Therefore, this animal is an invaluable resource for testing the safety and efficacy of therapeutic agents as well as candidate AIDS vaccines. As the only animal model for HIV, the chimpanzee may also be exceedingly useful in studies of the pathogenicity and natural history of this virus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Blood Diseases And Resources (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HB027091-001
Application #
2312584
Study Section
Project Start
1992-06-18
Project End
2002-06-17
Budget Start
1993-01-28
Budget End
1994-06-17
Support Year
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Southwest Foundation for Biomedical Research
Department
Type
DUNS #
City
San Antonio
State
TX
Country
United States
Zip Code
78245

  Publications

Rodriguez, Annette R; Hodara, Vida; Murthy, Kruthi et al. (2014) T cell interleukin-15 surface expression in chimpanzees infected with human immunodeficiency virus. Cell Immunol 288:24-30
Huang, Ying; Feld, Jordan J; Sapp, Ronda K et al. (2007) Defective hepatic response to interferon and activation of suppressor of cytokine signaling 3 in chronic hepatitis C. Gastroenterology 132:733-44
Elmowalid, Gamal A; Qiao, Ming; Jeong, Sook-Hyang et al. (2007) Immunization with hepatitis C virus-like particles results in control of hepatitis C virus infection in chimpanzees. Proc Natl Acad Sci U S A 104:8427-32
Rodriguez, Annette R; Arulanandam, Bernard P; Hodara, Vida L et al. (2007) Influence of interleukin-15 on CD8+ natural killer cells in human immunodeficiency virus type 1-infected chimpanzees. J Gen Virol 88:641-51
Wakita, Takaji; Pietschmann, Thomas; Kato, Takanobu et al. (2005) Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 11:791-6
Woollard, David J; Grakoui, Arash; Shoukry, Naglaa H et al. (2003) Characterization of HCV-specific Patr class II restricted CD4+ T cell responses in an acutely infected chimpanzee. Hepatology 38:1297-306
Thomson, Michael; Nascimbeni, Michelina; Havert, Michael B et al. (2003) The clearance of hepatitis C virus infection in chimpanzees may not necessarily correlate with the appearance of acquired immunity. J Virol 77:862-70
Grakoui, Arash; Shoukry, Naglaa H; Woollard, David J et al. (2003) HCV persistence and immune evasion in the absence of memory T cell help. Science 302:659-62
Thomson, M; Nascimbeni, M; Gonzales, S et al. (2001) Emergence of a distinct pattern of viral mutations in chimpanzees infected with a homogeneous inoculum of hepatitis C virus. Gastroenterology 121:1226-33
Dash, S; Kalkeri, G; McClure, H M et al. (2001) Transmission of HCV to a chimpanzee using virus particles produced in an RNA-transfected HepG2 cell culture. J Med Virol 65:276-81

Showing the most recent 10 out of 13 publications