The contractor shall serve as the Medical Coordinating Center for the Viral Activation Transfusion Study. This study is designed to determine if transfusion is followed by activation of HIV-1 and Cytomegalovirus (CMV) in HIV-1 infected persons and thereby adversely affects prognosis. It will also evaluate the role of donor leukocytes producing this activation by examining the effect of removing leukocytes by filtration or abolishing their ability to proliferate by gamma irradiation. Finally, the study will examine the persistence of donor lymphocytes after transfusion.

Agency
National Institute of Health (NIH)
Institute
Division of Blood Diseases And Resources (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HB057127-001
Application #
2312791
Study Section
Project Start
1994-12-01
Project End
1997-11-30
Budget Start
1995-06-15
Budget End
1996-05-31
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost
Name
New England Research Institute
Department
Type
DUNS #
153914080
City
Watertown
State
MA
Country
United States
Zip Code
02472
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