Abstract

Diagnose newborns with sickle cell disease and enter one and not more than ten. Maintain adequate retention and follow-up of patients. Perform routine """"""""steady state"""""""" visits on CSSCD patients as outlined in the protocol. Continue the collection of special tests to measure organ damage. Continue the collection of data on all acute and chronic events. Initiate the psychosocial protocol with a randomized set of patients as identified by the Statistical Coordinating Center. Continue the collection and shipping of blood samples for specific centralized determinations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Blood Diseases And Resources (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HB072993-017
Application #
3645806
Study Section
Project Start
1977-09-30
Project End
1988-09-30
Budget Start
1987-10-01
Budget End
1988-09-30
Support Year
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Liu, Ching-Ti; Monda, Keri L; Taylor, Kira C et al. (2013) Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet 9:e1003681
Musunuru, Kiran; Romaine, Simon P R; Lettre, Guillaume et al. (2012) Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project. PLoS One 7:e36473
Tin, Adrienne; Woodward, Owen M; Kao, Wen Hong Linda et al. (2011) Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele. Hum Mol Genet 20:4056-68
Liu, Ching-Ti; Garnaas, Maija K; Tin, Adrienne et al. (2011) Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. PLoS Genet 7:e1002264
Fox, Ervin R; Young, J Hunter; Li, Yali et al. (2011) Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet 20:2273-84
Böger, Carsten A; Chen, Ming-Huei; Tin, Adrienne et al. (2011) CUBN is a gene locus for albuminuria. J Am Soc Nephrol 22:555-70
Zhu, Xiaofeng; Young, J H; Fox, Ervin et al. (2011) Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium. Hum Mol Genet 20:2285-95
Pasaniuc, Bogdan; Zaitlen, Noah; Lettre, Guillaume et al. (2011) Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium. PLoS Genet 7:e1001371
Musunuru, Kiran; Lettre, Guillaume; Young, Taylor et al. (2010) Candidate gene association resource (CARe): design, methods, and proof of concept. Circ Cardiovasc Genet 3:267-75
Marcus, Gregory M; Alonso, Alvaro; Peralta, Carmen A et al. (2010) European ancestry as a risk factor for atrial fibrillation in African Americans. Circulation 122:2009-15