Abstract

The Contractor shall serve as a clinical center for the investigation of selected patient groups from the Cooperative Study of Sickle Cell Disease (CSSCD). The Contractor shall collaborate with other CSSCD investigators and NHLBI staff in the development and implementation of a protocol to continue to follow the newborn cohort and patients surviving beyond age thirty-five. The principal objective of this contract is to continue to follow the newborn cohort of patients presently being followed in the CSSCD to better understand severity, onset of early organ damage, and risk factors contributing to certain complications and outcome. This study is also intended to follow another important cohort of patients surviving beyond age thirty-five to better understand longevity and causes of death.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Blood Diseases And Resources (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HB097054-000
Application #
3646350
Study Section
Project Start
1988-10-01
Project End
1993-09-30
Budget Start
1988-10-01
Budget End
1989-09-30
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Children's Hospital & Res Ctr at Oakland
Department
Type
DUNS #
City
Oakland
State
CA
Country
United States
Zip Code
94609

  Publications

Musunuru, Kiran; Romaine, Simon P R; Lettre, Guillaume et al. (2012) Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project. PLoS One 7:e36473
Pasaniuc, Bogdan; Zaitlen, Noah; Lettre, Guillaume et al. (2011) Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium. PLoS Genet 7:e1001371
Tin, Adrienne; Woodward, Owen M; Kao, Wen Hong Linda et al. (2011) Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele. Hum Mol Genet 20:4056-68
Liu, Ching-Ti; Garnaas, Maija K; Tin, Adrienne et al. (2011) Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. PLoS Genet 7:e1002264
Fox, Ervin R; Young, J Hunter; Li, Yali et al. (2011) Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet 20:2273-84
Böger, Carsten A; Chen, Ming-Huei; Tin, Adrienne et al. (2011) CUBN is a gene locus for albuminuria. J Am Soc Nephrol 22:555-70
Musunuru, Kiran; Lettre, Guillaume; Young, Taylor et al. (2010) Candidate gene association resource (CARe): design, methods, and proof of concept. Circ Cardiovasc Genet 3:267-75
Marcus, Gregory M; Alonso, Alvaro; Peralta, Carmen A et al. (2010) European ancestry as a risk factor for atrial fibrillation in African Americans. Circulation 122:2009-15
Vichinsky, E P (1991) Comprehensive care in sickle cell disease: its impact on morbidity and mortality. Semin Hematol 28:220-6