The Transfusion Safety Study (TSS) is a multifaceted cooperative contract program, sponsored by the National Heart, Lung, and Blood Institute, to evaluate factors influencing the risk of transfusion-transmitted human immunodeficiency virus (HIV) infection and its progression to clinically significant manifestation. Participating clinical centers and blood services are located in four cities: New York, Miami, San Francisco, and Los Angeles. The coordinating center and central laboratories are located in Los Angeles and Seattle. Subjects include: 1) persons in the four highest prevalence areas of the United States who donated blood from September, 1984 through January, 1985, just before routine donor screening was begun; 2) recipients of components form ant-HIV-positive and anti-HIV- negative donors; 3) patients with congenital bleeding disorders receiving concentrates and components; 4) patients with congenital anemias receiving large numbers of transfusions; 5) untransfused subjects; 6) household contracts of patients wit bleeding disorders or anemias; 7) recipients of components from anti-HTLV-I-positive and negative components. The TSS is a unique study of the major aspects of transfusion medicine and AIDS. There are many aspects and activities in TSS, begun under the aegis of the original contract investigation, that require longer follow-up.

Agency
National Institute of Health (NIH)
Institute
Division of Blood Diseases And Resources (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HB097074-009
Application #
2313293
Study Section
Project Start
1989-02-15
Project End
1994-09-30
Budget Start
1991-05-09
Budget End
1991-11-15
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Southern California
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
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Operskalski, Eva A; Mosley, James W; Tobler, Leslie H et al. (2003) HCV viral load in anti-HCV-reactive donors and infectivity for their recipients. Transfusion 43:1433-41
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Kedes, D H; Operskalski, E; Busch, M et al. (1996) The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med 2:918-24
Diaz, R S; Sabino, E C; Mayer, A et al. (1995) Dual human immunodeficiency virus type 1 infection and recombination in a dually exposed transfusion recipient. The Transfusion Safety Study Group. J Virol 69:3273-81
Donegan, E; Wright, T L; Roberts, J et al. (1995) Detection of hepatitis C after liver transplantation. Four serologic tests compared. Am J Clin Pathol 104:673-9

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